Pariet, also known as Rabeprazole, is a key drug in treating acid reflux and gastroesophageal reflux disease (GERD). Available in 20 mg dosage, this medication helps millions of patients worldwide manage their symptoms and improve their quality of life. In this article, we look at how
Pariet alleviates these conditions and how you can purchase it.
How does Pariet work?
Pariet-rabeprazole belongs to a class of medications known as proton pump inhibitors (PPIs). The main mechanism of action is to block the end stage of acid production in the stomach, which significantly reduces the amount of acid. This alleviates acid reflux symptoms such as heartburn, acid taste in the mouth, and chest pain, and promotes healing of esophageal damage caused by excess stomach acid.
Benefits of using Pariet
One of the main benefits of Pariet drug is its ability to reduce acidity levels quickly, providing long-lasting relief. This makes it an ideal option for long-term management of GERD symptoms and preventing relapses. In addition, Pariet 20 mg is also effective in treating other related conditions such as stomach and duodenal ulcers.
Pariet online
Purchasing Pariet has been made easier with the availability of Mexican pharmacies online. When choosing a Mexican pharmacy online to buy Pariet, it is important to make sure that the provider is reliable and legitimate. Check for licenses and certifications that confirm the legitimacy of the pharmacy and the quality of the drugs offered. Platforms like
Mexican pharmacy online, offer a convenient way to order Pariet medication with home delivery. The purchase process is simple: you just need to select the desired number of Pariet tablets, add them to your cart and place the order, following the instructions on the website, which provides all the necessary information and customer reviews to help you make an informed choice.
Dosage of Pariet tablets in various cases
Pariet tablets, containing the active substance Rabeprazole, are an effective remedy for the treatment of various diseases associated with the gastrointestinal tract. Different dosages and regimens of Pariet are used depending on the specific disease and its severity.
Gastroesophageal reflux disease (GERD): To treat GERD and symptoms such as heartburn and acid regurgitation, adults are usually prescribed Pariet at a dosage of 20 mg once daily. The course of treatment may last from 4 to 8 weeks, depending on the severity of symptoms and response to treatment. In cases where symptoms return, long-term maintenance treatment with the same dose is possible at the discretion of the doctor.
Gastric and duodenal ulcers: For acute gastric ulcer, Pariet's dosage is usually 20 mg daily. Treatment usually lasts 6 weeks, but may be extended to 12 weeks if the ulcer does not heal completely. For acute duodenal ulcer, the recommended dosage is also 20 mg once daily for 4 weeks, with a possible extension to 8 weeks.
Helicobacter pylori eradication: In combination with appropriate antibiotics such as amoxicillin and clarithromycin, Pariet is used to eradicate H. pylori, which can lead to healing of ulcers and reduce the risk of ulcer recurrence. The dosage of Pariet in this case is usually 20 mg twice daily for 7 days.
Zollinger-Ellison syndrome: For the treatment of this rare condition characterized by excessive stomach acid production, the starting dose of Pariet may vary and often starts at 60 mg daily. The dosage may be adjusted by the physician depending on the patient's acid levels and clinical response, and some patients may require high doses for long periods of time.
Special Instructions:Pariet should be taken in the morning, 30–60 minutes before meals, to maximize its effectiveness.
Contraindications and side effects of the medicine Pariet
Although the drug Pariet is highly effective in the treatment of many conditions related to the stomach, it is still necessary to pay attention to some contraindications to its use and the occurrence of side effects.
Contraindications
Allergic reactions:Pariet should not be taken by people with known hypersensitivity to rabeprazole or any of the drug's excipients. Allergic reactions may manifest as skin rash, itching, swelling of the face, lips, tongue or throat, which may result in difficulty breathing.
Pregnancy and breastfeeding:Parieta use during pregnancy is possible only in cases when the expected benefit for the mother exceeds the potential risk for the fetus. It is also necessary to take the drug with caution during breastfeeding, as it is not known whether rabeprazole is excreted with breast milk.
Pediatric age: The drug is not recommended for use in children under 12 years of age, as the safety and efficacy of its use in this age group have not been established.
Side effects
Common side effects: Include headaches, diarrhea, nausea, vomiting, and constipation. These symptoms are usually minor and often go away on their own.
Infectious diseases: Use of Pariet may increase the risk of intestinal infections, such as those caused by the bacterium Clostridium difficile, especially with long-term use.
Digestive disorders: Gas, abdominal pain and discomfort may occasionally occur.
Serious side effects: In rare cases, more serious conditions such as pancreatitis, severe allergic reactions, jaundice and interstitial nephritis may develop. If symptoms indicative of these conditions occur, you should seek immediate medical attention.
Effect on absorption of vitamins and minerals: Prolonged use of Pariet may lead to vitamin B12 deficiency, as a decrease in gastric acidity reduces the ability of the body to absorb this vitamin from food. It is also possible to reduce the absorption of magnesium, which in rare cases can lead to serious deficiencies of this mineral, manifested as fatigue, heart rhythm disturbances, seizures or mood changes.
Effects on bone tissue: Studies have shown that long-term use of proton pump inhibitors such as Pariet may be associated with a small increase in the risk of bone fractures, especially in elderly patients and those taking high doses or using the medication for more than one year.
Therapeutic effect of Pariet
The therapeutic effect of Pariet begins quite quickly. After taking the tablet, the effect occurs within one hour, with a maximum reduction in acidity achieved after about two hours. This rapid onset of action makes Pariet particularly useful for relieving the symptoms of acid reflux and other related conditions.
The duration of Pariet's therapeutic action depends on the dose, but it usually lasts up to 24 hours. This means that taking a single tablet daily can provide a whole day's relief from excess acidity. This prolonged action is especially important for patients who need continuous stomach acid control to avoid long-term complications such as esophageal erosions or ulcers.
Half-life of Parieta
The half-life of a medicine is the time it takes for the concentration of the substance in the blood to decrease by 50%. The half-life of rabeprazole, the active ingredient in Parieta, is approximately 1 to 2 hours. However, despite its relatively short half-life, the clinical effects of the drug last significantly longer due to its ability to produce prolonged suppression of gastric acid secretion.
This discrepancy between the short half-life and prolonged therapeutic effect is explained by the mechanism of action of rabeprazole. Rabeprazole actively binds to proton pumps in gastric cells, blocking the final step of acid production. This process is not reversible, and new proton pumps must be synthesized by the cells to restore acidity, which takes time.
Interaction of Pariet with other medicines
The drug Pariet may interact with other medicines, which may affect its effectiveness or cause undesirable effects. In this article, we will review the main interactions of Pariet with other drugs.
Drugs that alter the pH of gastric juice: Rabeprazole, as a proton pump inhibitor, reduces the acidity of gastric juice, which can affect the absorption and effectiveness of other drugs. For example, drugs that require a certain level of acidity for adequate absorption, such as ketoconazole or itraconazole (antifungal agents), may be less effective when taken concomitantly with Pariet.
Drugs metabolized by the cytochrome P450 system: Rabeprazole is metabolized in the liver by the cytochrome P450 enzyme system, particularly CYP2C19 and CYP3A4. Although rabeprazole has less effect on these enzymes than some other proton pump inhibitors, it may still interact with drugs that are also metabolized by these enzymes. For example, dosage adjustments may be necessary if taken concomitantly with cyclosporine (an immunosuppressive drug) or diazepam (an anxiolytic).
Antithrombotic and anticoagulant drugs: Studies have shown that concomitant administration of rabeprazole and clopidogrel (an antithrombotic drug) may reduce the antithrombotic effect of the latter. However, subsequent studies and clinical data do not always support this effect, so the risks and benefits must be carefully weighed in each case.
Calcium supplements and bisphosphonates: Since Pariet reduces gastric acidity, it may affect calcium absorption, which is important to consider in patients taking calcium supplements or bisphosphonates (osteoporosis drugs). Decreased calcium absorption can potentially exacerbate calcium deficiency-related conditions and increase the risk of osteoporosis, especially in elderly patients or with long-term use of Parieta.
Methotrexates: Special attention should be paid when Pariet and high doses of methotrexate, used in the treatment of some cancers and severe forms of psoriasis and rheumatoid arthritis, are used concomitantly. In some cases, rabeprazole may increase serum concentrations of methotrexate, potentially leading to toxic effects. In such cases, temporary discontinuation of Pariet may be necessary, or careful monitoring of methotrexate levels in the blood may be required.
Antacids: Although antacids are often used for rapid relief of heartburn symptoms, their concomitant administration with Pariet may affect the absorption of rabeprazole to some extent. This is generally not considered a significant problem, but it is recommended that an interval of several hours be observed between taking these two types of medications to minimize possible interactions.
Food: Although Pariet is less dependent on the timing of administration compared to some other proton pump inhibitors, it is optimal to take it 30–60 minutes before meals, especially before breakfast. This provides the best absorption and most effective reduction of gastric acidity.
Pariet 20 mg remains one of the most reliable and effective remedies for controlling acid reflux and GERD. With the ability to buy Pariet online through a Mexican pharmacy, the management of these conditions becomes more accessible to a wider audience of patients. If you suffer from acid reflux symptoms, consider discussing Pariet with your doctor to determine if it is right for you to treat and alleviate your symptoms.
